17 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... of Systemic Lupus ... autoantibodies that will cause ... thrombosis and/or blood-brain ... #CNS #neurology
Alice in Wonderland Syndrome
What? Metamorphophsia - Distortions of the visual perceptions with changes in size (micro
CNS: parietal ... lobe • Retina • Systemic ... encephalitis) • Brain ... • Psychiatric disorders ... diagnosis #neurology #differential
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential ... Diagnosis and Workup ... l MD SOAP) - Risks ... test, ANA (e.g., SLE ... #Workup #hematology
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent
Multiple Ring-Enhancing Lesions:
 • Toxoplasmosis (CD4 < 100)
 • Other
CNS Ring-Enhancing ... + toxo IgG • CNS ... 30% present w/ CNS ... #differential # ... diagnosis #causes
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
affecting the brain ... (CNS) involvement ... Inflammatory causes ... optica spectrum disorder ... #inflammatory #differential
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Weakness - Differential ... pulmonary etc) • CNS ... -> PNS -> NMJ - ... dystrophies Work ... cryoglobulins • PNS
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... permanent alopecia Differential ... • May involve PNS ... and CNS • Headache ... Thrombosis highest risk
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Parotid swelling CNS ... (CNS): demyelinating ... • 8%-27% for CNS ... Nephrogenic DI Hematologic
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
syndrome): - Hematologic ... mg/dL or > 25 % rise ... Treat underlying cause ... ) - Symptoms: CNS ... ) - Symptoms: CNS
Polycythemia - Differential Diagnosis Algorithm
Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... circulation = risk ... frequently affected systems ... Better call hematology ... #hematology