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diagnosis management differential oncology algorithm clinical rash disease anemia erythematosus intravascular leukemia lupus mds myelodysplastic sle systemic workup acne activation
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... • Risks: infection ... only curative treatment ... #hematology #oncology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... deficiencies - PNH ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Recurrent / Breakthrough DVT During Anticoagulation Subtherapeutic Anticoagulation Hypercoagulable State - Antithrombin deficiency - Hypercoagulability ot
APLS - MPN/PNH ... Structural - Pelvic masses ... - May-Thurner syndrome ... anticoagulation #hematology
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
Cardiovascular Causes ... - Water - Pus ... Hepatopulmonary syndrome ... Other Causes ... Transverse myelitis • Hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
• Acquired Risk ... Testosterone - Coumadin skin ... • Nephrotic Syndrome ... cardiovascular risk ... pathophysiology #hematology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
for secondary causes ... eosinophilia (common causes ... glucocorticoid treatment ... symptoms (eg, skin ... Differential #diagnosis #hematology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Dermatologic Manifestations ... GPA causes disease ... • Goodpasture syndrome ... Polyangiitis #GPA #dermatology ... rash #diagnosis #rheumatology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
blisters containing pus ... Rule out other causes ... and lower jaw Treatment ... #Rheumatology # ... diagnosis #management #Dermatology
Behcet's Syndrome - Treatment Ulcers: • Treatment: Topical steroids • Prevention: Colchicine • Azathioprine for refractory disease Arthritis:
Behcet's Syndrome ... : • Treatment: ... refractory disease Skin ... Behcets #disease #Syndrome ... #pharmacology #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... hemoglobinuria (PNH ... differential #diagnosis #hematology
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