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differential management erythematosus oncology sle syndrome systemic activation algorithm blood cerebritis clinical disorders dyspnea extravascular finger flexor hemolysis hemolytic intravascular
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... autoantibodies that will cause ... permeability Diagnosis ... Erythematosus #SLE #CNS ... #neurology #rheumatology
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
- Differential Diagnosis ... - Water - Pus ... Barre - ALS - Transverse ... myelitis • Hematology ... : - Anemia •
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
and Differential Diagnosis ... Lymphadenopathy, CNS ... Pelger-Huet, Macrocytic anemia ... Amy Chung, MD, MSc ... Blood #Disorders #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... hemoglobinuria (PNH ... usually IgG) (e.g. lupus ... #hematology #anemia
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Scleromyxedema (CNS ... +PNS+GI+Endocrine ... (-) hemolytic anemia ... to cold IgG • Lupus ... Paraproteinemias #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• May involve PNS ... and CNS • Headache ... neuropathy • Transverse ... lymphopenia, low PLT • Anemia ... #Rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
nervous system (CNS ... with leukopenia, anemia ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Parotid swelling CNS ... nervous system (CNS ... • 8%-27% for CNS ... phenomenon (16%) MSK ... Sjogrens #Syndrome #Rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... leukostasis syndrome: CNS ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Trigger Finger - Stenosing flexor tendon tenosynovitis There is a change in the slip between the tendon
Trigger Finger - ... The diagnosis is ... tenosynovitis #msk ... #clinical #physicalexam ... #orthopedics #rheumatology
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