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Hemolytic Anemia - Hemolysis Diagnostic Workup

Infographic by: Howard Ong

#Hemolysis #Hemolytic #Anemia #Algorithm #MAHA #TTP #Diagnosis #Workup
Hemolytic Anemia ... Workup Infographic ... #Algorithm #MAHA ... #TTP #Diagnosis ... #Workup #Hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
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Causes of Extravascular ... • PCH • PNH ... Shearing • MAHA ... (TTP, DIC, HUS) ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... thrombocytopenic purpura (TTP ... hemoglobinuria (PNH ... usually IgG) (e.g. lupus ... differential #diagnosis #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
disease - DIC/TTP ... /HUS - Hemolytic ... - APLS • Acute ... Differential #Diagnosis #hematology ... #rheumatology #
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... platelet decrease - PNH ... thrombocytopenia - DIC, TTP ... Differential #Diagnosis #Algorithm ... #workup #hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
fulminans - DIC - TTP ... Autoimmune Vasculitis (lupus ... - APLS - HIT ... deficiency Work ... #Causes #dermatology
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm
INDICATIONS FOR TESTING:
 • Vascular thrombosis
Hypercoagulable Workup ... Algorithm INDICATIONS ... maternal chromosomal causes ... excluded Testing: • Lupus ... #hematology