17 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... autoantibodies that will cause ... prevention (statin for CVA ... #neurology #rheumatology ... cerebritis #diagnosis #management
Recurrent / Breakthrough DVT During Anticoagulation

Subtherapeutic Anticoagulation
Hypercoagulable State 
 - Antithrombin deficiency 
 - Hypercoagulability ot
Hypercoagulability ot Ca ... APLS - MPN/PNH ... - May-Thurner syndrome ... anticoagulation #hematology ... #differential #algorithm
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
et diutinum Neurologic ... neuropathy) • Systemic ... +PNS+GI+Endocrine ... Thrombosis in vascular beds-renal ... Paraproteinemias #Hematology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
FLAGS - In all cases ... guidelines General - Systemic ... splenomegaly, abnormal neurology ... #Limping #NWB #Algorithm ... Pathway #Child #Peds
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Muehrcke's Lines - Transverse ... • Nephrotic syndrome ... #Secondary #dermatology ... Differential #Diagnosis #Algorithm ... #causes
Behcet's Syndrome - Treatment
Ulcers:
 • Treatment: Topical steroids
 • Prevention: Colchicine
 • Azathioprine for refractory disease
Arthritis:
Behcet's Syndrome ... Neuro disease: • Systemic ... Behcets #disease #Syndrome ... #Treatment #management ... #pharmacology #rheumatology
Neuromyelitis Optica (NMO) - Clinical Manifestations
 • Optic neuritis: Reduced visual acuity, ranging from mild to
involvement: Intractable nausea ... Many others • Transverse ... pain • Extra-CNS ... autoimmune disorders (Systemic ... Manifestations #diagnosis #neurology
Hyponatremia - Differential Diagnosis Algorithm
Hypovolemic - Give volume
Hypervolemic (Edematous) - Look for and treat underlying cause
treat underlying cause ... cirrhosis, nephrotic syndrome ... Pulmonary Diseases, CNS ... Disease, Meds ( ... #diagnosis #nephrology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... Central nervous system ... peripheral neuropathy, transverse ... Nephrogenic DI Hematologic ... Diagnosis #Management
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Systemic disease ... skin injury) • Neurologic ... basal ganglia, CNS ... #diagnosis #management ... signs #symptoms #rheumatology