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diagnosis rheumatology differential management symptoms vasculitis anemia aplastic autoimmune behcet classification dermatology disease leukemia manifestations monoclonal myopathy myositis neuromyelitis nmo
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
et diutinum Neurologic ... Amyloidosis (CVS+PNS ... Episodic angioedema+eosinophilia ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
involvement: Intractable nausea ... Many others • Transverse ... pain • Extra-CNS ... Manifestations #diagnosis #neurology ... #symptoms #signs
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Episcleritis Signs ... Causes: - Idiopathic ... , breast CA - Hematologic ... #diagnosis #dermatology ... #oncology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
response to local skin ... injury) • Neurologic ... test (this is a skin ... diagnosis #management #signs ... #symptoms #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
• (Peripheral eosinophilia ... • Tumor lysis syndrome ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... and petechiae Causes ... - Hepatitis, eosinophilic ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... , neurologic, and ... cognitive impairment, neurologic ... Polyangiitis): • Eosinophilia ... tract, and often causes
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Lacrimal swelling • Skin ... Hypocomplementemia • Can cause ... peripheral neuropathy, transverse ... amyloidosis, PAH Skin ... Nephrogenic DI Hematologic
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
• EGPA: - Eosinophilia ... tract, and often causes ... • Cogan Syndrome ... purpura: strong sign ... differential #diagnosis #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
) • Anti-Mi2 (skin ... papules and Gottron sign ... ) • Shawl sign ... aspiration > 50% of pts ... statins - probably caused
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