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causes potassium hematology hyperkalemia lysis algorithm differentiation diuresis excretion gravis leukostasis low medications myasthenia pharmacology renal rhabdomyolysis table uricacid
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... (both ALL and AML ... : • IV fluids ... #TLS #oncology ... #management #UricAcid
Causes of Hypokalemia Transcellular Shifts: - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
plasma insulin (treatment ... Hypomagnesemia, Acute ... and lymphomas, IV ... #Causes #differential ... #diagnosis #nephrology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
• Triggers: Diuretics ... - ACS, AKI, acute ... hydration - Hyperkalemia ... #TLS #diagnosis ... #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
• Attempt if high ... Supportive Care: Diuresis ... #APML #diagnosis ... #management #hematology ... #oncology
Hypokalemia Evaluation Algorithm Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
urinary losses: • High ... Renin secreting tumor ... #diagnosis #Algorithm ... #differential # ... potassium #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... • K sparing diuretics ... Transfusion reaction - Tumor ... lysis syndrome ... #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... • K sparing diuretics ... Transfusion reaction - Tumor ... lysis syndrome ... #nephrology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
• Diagnosis of ... irrigation • Management ... ; High-Ceiling Diuretics ... Tolvaptan) • Treatment ... #Nephrology #Pharmacology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Diagnosis Framework ... and Management ... Loop diuretics for ... #Diagnosis #Management ... #nephrology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
with: - Thymic tumors ... life-threatening Differential ... myasthenia Diagnosis ... aspiration and acute ... #management #neurology
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