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diagnosis differential hematology management algorithm anemia clinical nephrology hepatology microscopy treatment blood classification hemolytic oncology renal syndromes autoimmune echocardiogram fever
Plasmodium Falciparum Blood Smear. Key features suggesting Plasmodium falciparum: - extreme parasitemia - normocytic RBCs (vivax, ovale prefer big
Falciparum Blood Smear ... multiples per RBC ... P. falciparum causes ... human malaria cases ... rare in blood smears
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Normochromic RBCs on Smear ... RBCs Decreased RBC ... Spherocytes on Smear ... Disorder • RBC ... Diagnosis #Algorithm #Causes
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome—due to GBM disruption. Hypertension. t BUN and creatinine.
and Nephrotic Syndromes ... Nephritic syndrome—due ... RBC casts in urine ... but in severe cases ... Nephritic #Nephrotic #Syndromes
Nephritic vs Nephrotic Syndrome Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes. Step
Nephritic vs Nephrotic Syndrome ... nephrotic/nephritic syndromes ... glomerular hematuria (RBC ... casts or dysmorphic ... Nephritic #Nephrotic #Syndrome
Beautiful acanthocytes/spur cells in a patient with McLeod Syndrome. X-linked disorder characterized by reduced expression of
patient with McLeod Syndrome ... expression of Kell RBC ... SpurCells #McLeod #Syndrome ... #Smear #Pathology
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
disease - Alport syndrome ... pain hematuria syndrome ... hematuria: - RBC ... - Dysmorphic RBC ... • Nutcracker syndrome
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Normal Blood Smear ... Neutrophils - Low RBC ... Myelodysplastic Syndromes ... Diagnosis #Algorithm #Causes
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
2) External (RBC ... Drug-associated, PCH, Evans Syndrome ... 3) Internal (RBC ... Peripheral Blood Smear
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
↑ LDH • Anti-RBC ... C3d • Blood smear ... 2) LOOK FOR a cause
Takotsubo Cardiomyopathy - Right Ventricular Involvement In up to 1/4 of cases of stress cardiomyopathy (takotsubo),
In up to 1/4 of cases ... #BrokenHeart #Syndrome ... Echocardiogram #A4C
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