22 results
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Gaucher Disease ... Pathophsiology ... Neurological involvement (type ... #Diagnosis #Signs ... #Symptoms
Causes of Peripheral and Central Vertigo
PERIPHERAL VERTIGO
1. Benign paroxysmal positional vertigo (BPPV) - Short-lived (typically less
Méniére's disease ... most common type ... course of the disease ... Disease onset usually ... signs or symptoms
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Endocarditis, Aortic ... pain (20%) Renal disease ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
neurodegenerative disease ... • Unilateral optic ... Signs and symptoms ... objective evidence of neurologic ... diagnosis #management #neurology
Neuromyelitis Optica (NMO) - Clinical Manifestations
 • Optic neuritis: Reduced visual acuity, ranging from mild to
Manifestations • Optic ... mainly AQP4-lgG disease ... mainly MOG-lgG disease ... Manifestations #diagnosis #neurology ... #symptoms #signs
Keratoconus: Pathogenesis and Clinical Findings
Genetics
 • Family history of keratoconus
 • Ehlers-Danlos syndrome
 • Down, Turner,
Changes in collagen types ... rubbing • Atopic diseases ... / Symptoms / Complications ... • Rizutti's Sign ... #Keratoconus #pathophysiology
Optic Neuritis - Diagnosis and Management
 • Epidemiology: Female (75%), 18-50 years,
caucasian
 • Symptoms: Moderate visual
Optic Neuritis - ... caucasian • Symptoms ... Unilateral • Signs ... other auto-immune diseases ... Management #treatment #rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Syndrome Systemic disease ... skin injury) • Neurologic ... meningitis), MCC CNS symptoms ... diagnosis #management #signs ... #symptoms #rheumatology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
• Inflammatory Disease ... • Hematologic Disease ... Occlusion #CRAO #pathophysiology ... ophthalmology #diagnosis #signs ... #symptoms
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
< 30 years - Aorta ... branches • GCA: - Aorta ... Presentation - Systemic Symptoms ... purpura: strong sign ... differential #diagnosis #rheumatology