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differential algorithm management oncology anemia vasculitis classification hemophagocytic hepatology hlh injury liver lymphohistiocytosis agglutinin aplastic autoimmune cd4 cold diffuse disease
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... → Refer to hematology ... for workup, including ... BM Bx Consider ... #Algorithm #hematology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... to Kidney: Anti-GBM ... ANCA (C-ANCA): GPA ... #differential #diagnosis ... #algorithm #rheumatology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Infectious • EBV ... Fatigue • Acute ... Reed-Sternberg Cells ... #Hematology #Oncology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... - Differential Diagnosis ... C, A, E, B, D, EBV ... #Causes #Acute ... #algorithm #hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... When do you do a BM ... #Causes #Workup ... #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... HIV, HBV, EBV, ... gastric tumors • Hematology ... #differential #diagnosis ... #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... High in acute blood ... in bone marrow (BM ... under 2%, then BM ... #Workup #Hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... Algorithm Vascular Causes ... HBV, HCV, HEV, EBV ... #differential #diagnosis ... #algorithm #hepatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... Infections+++: Virus (EBV ... biologics (CMV +++, EBV ... Drugs, Unknown cause ... treatment #summary #rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Toxic injury to BM ... and petechiae Causes ... Parvovirus B19 - EBV ... Anemia #oncology #hematology ... #diagnosis #management
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