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diagnosis disease hematology agglutinin anemia antibodies associations autoantibodies cold diseases gap globulin hemolytic management myopathy myositis protein proteingap stills treatment
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
fraction < 20% Differential ... Diaqnoses: • Infectious ... Coxsackie, CMV, EBV ... Prunelle Getten #AdultOnset ... management #treatment #rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Anti-mitochondrial (AMA ... biliary cirrhosis (PBC ... Celiac disease Anti-GBM ... diseases #diagnosis #table ... #rheumatology #
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
, autoimmune disorder ... - Mycoplasma, EBV ... CLL (older) • Autoimmune ... younger pts) Differential ... Disorders Such As
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Include: • Viral infections ... acute HIV, HBV, EBV ... Sarcoidosis) • Liver ... Cirrhosis, ETOH, autoimmune ... Gap #ProteinGap #differential
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... Tenderness → Consider infectious ... RP-ILD), dermato-rheumatologic ... • ANA < 20 % IBM ... #differential #
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