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diagnosis cns disease hematology neurology vasculitis adultonset agglutinin aids anemia antibodies associations autoantibodies autoimmune classification cold diseases encephalitis gap globulin
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Anti-mitochondrial (AMA ... biliary cirrhosis (PBC ... Celiac disease Anti-GBM ... diseases #diagnosis #table ... #rheumatology #
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad: Fever ... fraction < 20% Differential ... Diaqnoses: • Infectious ... Coxsackie, CMV, EBV ... management #treatment #rheumatology
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework Viral Encephalitis: MCC: Enteroviruses (e.g., coxsackievirus
CNS Infections - ... virus • CMV • EBV ... /l is regarded as ... rav7ks #CNS #Infections ... #differential #
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
HIV / AIDS - Differential ... • Symptoms: AMS ... symptoms such as ... effect/Edema • EBV ... #differential #
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Mycoplasma, EBV ... younger pts) Differential ... Disorders Such As ... Hemoglobinuria (PCH ... hemolytic #anemia #hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Vasculitis Differential ... to exclude are infections ... pain and GN Anti-GBM ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitides - Differential ... glomerulonephritis) • Anti-GBM ... Coronary arteries - Fever ... to exclude are infections ... #diagnosis #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Include: • Viral infections ... acute HIV, HBV, EBV ... Sarcoidosis) • Liver ... Gap #ProteinGap #differential ... #diagnosis #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... Tenderness → Consider infectious ... RP-ILD), dermato-rheumatologic ... • ANA < 20 % IBM ... #differential #
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