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diagnosis injury algorithm causes hematology transaminitis lfts workup acute autoimmune biliary cholangitis cirrhosis comparison disorders elevated gap globulin hepatocellular hodgkins
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute Liver ... Hepatocellular - Liver ... , E, B, D, EBV, ... Artery: Shock Liver ... Acute #algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Injury: • Infectious ... HBV, HCV, HEV, EBV ... #differential # ... diagnosis #algorithm #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... 10-20x normal - Infection ... (EBV/CMV), Alcoholic ... #Patterns #Liver ... #Injury #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury → liver ... Diagnosis: • Infections ... C/D/E, EBV, CMV, ... #Diagnosis #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Transaminitis - Differential ... Diagnosis • Infectious ... HAV, HCV, HEV, EBV ... Trauma: Shock liver ... Diagnosis #causes #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
cholestasis → Cirrhosis/Liver ... or higher • Liver ... bile ducts Differential ... Diagnosis: • Viral hepatitis ... fungal, viral infections
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Immunosuppression (e.g., HIV), EBV ... infection, Autoimmune ... the spleen or liver ... Extranodal disease: GI ... #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
procedures - Infection ... : INR/PT, aPTT(liver ... . pylori test (GI ... bypass), LFT (liver ... When do you do a BM
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Include: • Viral infections ... acute HIV, HBV, EBV ... Sarcoidosis) • Liver ... , PBC, PSC, Viral ... Gap #ProteinGap #differential
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... Tenderness → Consider infectious ... • ANA < 20 % IBM ... Other Diseases: • PBC ... , autoimmune hepatitis
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