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diagnosis hepatology algorithm causes injury lfts rheumatology transaminitis acute antibodies associations autoantibodies cns comparison diseases elevated gap globulin hepatocellular hiv
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute Liver ... Hepatocellular - Liver ... C, A, E, B, D, EBV ... Other: NAFLD, Autoimmune ... Artery: Shock Liver
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... HBV, HCV, HEV, EBV ... Celiac disease • Autoimmune ... : Autoimmune hepatitis ... #differential #
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury → liver ... Hepatocellular Liver ... A/B/C/D/E, EBV, ... Other: NAFLD, Autoimmune
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Transaminitis - Differential ... HAV, HCV, HEV, EBV ... Trauma: Shock liver ... obstruction syndrome • Autoimmune ... #Differential #
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
common in SLE, autoimmune ... hepatitis Anti-CCP ... Dermatomyositis Anti-LKM (liver ... biliary cirrhosis (PBC ... Celiac disease Anti-GBM
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Ischemia • Autoimmune ... Bile Ducts • PSC ... • Alcoholic hepatitis
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Immunosuppression (e.g., HIV), EBV ... infection, Autoimmune ... the spleen or liver ... lymphadenopathy, mass ... #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
acute HIV, HBV, EBV ... Sarcoidosis) • Liver ... Cirrhosis, ETOH, autoimmune ... hepatitis, PBC, ... PSC, Viral hepatitis
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
Infection in HIV / AIDS ... - Differential ... lesions < 4cm + mass ... effect/Edema • EBV ... #diagnosis #AIDS
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... • ANA < 20 % IBM ... Other Diseases: • PBC ... , autoimmune hepatitis ... #differential #
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