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Hypoxia and Hypoxemia - Overview Hypoxia - insufficient oxygen delivered to tissues to meet demands Hypoxemia - low
O2 is inspired) PAO2 ... reaches the alveoli) PaO2 ... Low SvO2 → Low PaO2 ... sepsis) - High PaO2 ... diagnosis #causes #pathophysiology
Markers of Organ Dysfunction in Severe Sepsis Altered consciousness Confusion Psychosis Tachycardia Hypotension Altered CVP Altered
Altered CVP Altered PAOP ... Tachypnoea PaO2 ... <70mmHg SaO2 < ... 90% PaO2/FiO2 300%
Respiratory Oxygenation Cycle - Pathophysiology PO2 and PCO2 By @rev.med #Respiratory #Oxygenation #Cycle #circulation #pathophysiology
Oxygenation Cycle - Pathophysiology ... PO2 and PCO2 By ... #circulation #pathophysiology
Arterial Blood Gas (ABG) Analysis - Metabolic + Respiratory Acidosis + Alkalosis pH ↓ pCO2 ↓ -
Alkalosis pH ↓ pCO2 ... acidosis pH ↑ pCO2 ... alkalosis pH ↑ pCO2 ... alkalosis pH ↓ pCO2 ... #Arterial #BloodGas
Perform computations online at: ScyMed.com 6th ED ICU-card «ICU, Formulas & Drugs» HEMODYNAMIC PATTERNS Condition SAP CVP PAP PCWP CO C(a-v)02 PVR SVR Hypovolemic shock ↓ ↓ ↓ ↓ ↓ ↑ ↑ ↑ Cardiogenic shock ↓ 1 ↑ 1 1 ↑ Septic shock ↓ ↓ ↓ ↓ ↑ ↓ ↓ ↓ Cardiac Tamponade . ↑ ↑ 1 ↓ → ↑ RV
-PECO2))/PaCO2 ... age-corrected PAO2 ... /R) | Pa02 80- ... ))+(Pa02*0.0031) ... )-(CvO2) Pa02
Approach to the A-a Gradient A-a gradient = PAO2 - PaO2 A-a gradient = [FiO2 x (Patm -
A-a gradient = PAO2 ... - PaO2 A-a gradient ... (Patm - 47) - (PaCO2 ... /0.8)] - PaO2 Simplified ... /0.8)] - PaO2 Normal
Acid Base and Blood Gas Analysis 1. pH - What’s the primary disturbance? 2. pCO2 - What’s the
2. pCO2 - What’s ... the pCO2? ... #respiratory #bloodgas
Oxygen-Hemoglobin Dissociation Curve Left Shift (↓ O2 unloading to tissue), Left = Lower: • ↓ H+ (↑
+ (↑ pH) • ↓ PCO2 ... + (Acid) • ↑ PCO2 ... Dissociation #Curve #pathophysiology
Blood Gas (ABG) Interpretation and Acid-Base Pathology 1- Does the patient have an acidosis or an alkalosis?
Look at the pCO2 ... Metabolic Equal (If pCO2 ... the change in pCO2 ... calculate the expected pCO2 ... Interpretation #BloodGas
Oxygen Delivery Equation DO2 = CO x {(1.39 x Hb x sO2) + (PaO2 x 0.03)} DO2 =
x Hb x sO2) + (PaO2 ... effective hemoglobin PaO2 ... in your hands = PaO₂ ... Delivery #Equation #pathophysiology
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