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Hypoxia and Hypoxemia - Overview Hypoxia - insufficient oxygen delivered to tissues to meet demands Hypoxemia - low
O2 is inspired) PAO2 ... reaches the alveoli) PaO2 ... Low SvO2 → Low PaO2 ... Low SvO2 → Low PaO2 ... sepsis) - High PaO2
Markers of Organ Dysfunction in Severe Sepsis Altered consciousness Confusion Psychosis Tachycardia Hypotension Altered CVP Altered
Altered CVP Altered PAOP ... Tachypnoea PaO2 ... <70mmHg SaO2 < ... 90% PaO2/FiO2 300%
Approach to the A-a Gradient A-a gradient = PAO2 - PaO2 A-a gradient = [FiO2 x (Patm -
A-a gradient = PAO2 ... - PaO2 A-a gradient ... (Patm - 47) - (PaCO2 ... /0.8)] - PaO2 Simplified ... /0.8)] - PaO2 Normal
Perform computations online at: ScyMed.com 6th ED ICU-card «ICU, Formulas & Drugs» HEMODYNAMIC PATTERNS Condition SAP CVP PAP PCWP CO C(a-v)02 PVR SVR Hypovolemic shock ↓ ↓ ↓ ↓ ↓ ↑ ↑ ↑ Cardiogenic shock ↓ 1 ↑ 1 1 ↑ Septic shock ↓ ↓ ↓ ↓ ↑ ↓ ↓ ↓ Cardiac Tamponade . ↑ ↑ 1 ↓ → ↑ RV
-PECO2))/PaCO2 ... age-corrected PAO2 ... /R) | Pa02 80- ... ))+(Pa02*0.0031) ... )-(CvO2) Pa02
ABG vs VBG: Arterial vs Venous Blood Gases ABG PROS: Tells you exactly what the arterial environment looks
looks like (pH, PaCO2 ... #Correlation #Comparison ... #pH #pCO2 #Diagnosis
Respiratory Oxygenation Cycle - Pathophysiology PO2 and PCO2 By @rev.med #Respiratory #Oxygenation #Cycle #circulation #pathophysiology
Pathophysiology PO2 ... and PCO2 By @rev.med
Hypoxemia vs Hypoxia Hypoxemia - Partial pressure of arterial oxygen (PaO2) is below normal Hypoxia - Insufficient oxygen
arterial oxygen (PaO2 ... compensate for low PaO2 ... differential #diagnosis #comparison
Oxygen Saturation - Measurement Techniques and Limitations • Sp02 - Cutaneous pulse oximeter • SaO2 Calculated
pulse oximeter • SaO2 ... ABG device • SaO2 ... pulmonary #diagnosis #comparison
Hepatopulmonary Syndrome HPS - Diagnosis: 1. Patients with liver disease 2. Alveolar-arterial oxygen gradient (AaP02) >15 mmHg
Moderate HPS: ≥ 60 PaO2 ... Severe HPS: ≥ 50 PaO2 ... Very severe HPS: PaO2
Berlin Criteria for Acute Respiratory Distress Syndrome (ARDS) - Respiratory symptoms must have begun within one
week of a known clinical ... inspired oxygen (PaO2 ... - 200 mm Hg < PaO2 ... - 100 mm Hg < PaO2 ... H2O - Severe - PaO2
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