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differential leukemia chronic liver lymphocytic syndrome workup aflp apml biliary bone cholangitis classification cvid dermatology differentiation enlarged essential et fatty
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Congestive • Cirrhosis ... Malignant • Lymphoma ... • Sickle Cell ... #Algorithm #Causes ... #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... -> AML: Blast crises ... Transformation: • Complication ... #Hematology #Oncology ... #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... Diagnosis: • ... cells can indicate disease ... #workup #oncology ... #hematology
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Causes of Bone/Joint ... Cell Disease Vaso-occlusive ... other orthopedic complications ... #differential #diagnosis ... #causes #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
thrombocytopenia Complications ... lymphoma (Richter ... chemotherapy for low-risk disease ... #hematology #hemeonc ... #diagnosis #management
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Female:Male 9:1 • Common ... 65 years PBC Pathophysiology ... intralobular bile ducts causes ... Endocrinopathy, Lymphoma ... #workup #hepatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... noninfectious complications ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
hemolytic anemia • Pain ... (NSHL) - (most common ... number of sites of disease ... #hematology #oncology ... #management
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
vomiting, abdominal pain ... ↓Antithrombin Ill ... Monitor and Treat Complications ... Liver #Pregnancy #hepatology ... #management #pathophysiology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... • Induce blast cell ... effusions, weight gain ... #management #hematology ... #oncology
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