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differential management infections pulmonary hiv infectiousdiseases rheumatology cd4 cell disease emergencies evaluation gammopathy hemeonc histiocytosis igg4 langerhans lch lung mgrs
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... , biliary, renal ... , lung, lymph node ... concentration PET-CT ... #phenotypes #workup
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
mononeuritis multiplex WORKUP ... Other tests: • CT ... Goodpasture's cause ... sparing of the lung ... #management #treatment
Pulmonary Infections in HIV-AIDS Bacterial: • No organism identified, Strep pneumoniae, H. influenzae, S.aureus, Streptococcus Grp
Infections in HIV-AIDS ... failure, COPD, Lung ... CXR +/- High res CT ... Infectious Diseases ... #workup #diagnosis
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
HIV / AIDS - Differential ... Antimicrobial treatment ... enhancement on CT ... Demyelinating disease ... caused by the JC
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
- Differential Diagnosis ... Framework Disease ... • CT: Halo sign ... Lymphadenopathy, CNS ... Infections #HIV #AIDS
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... cirrhosis: 3%-20% Renal ... Distal (Type I) renal ... MALT Lymphoma • Lung ... Adenocarcinoma Treatment
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
suspected) - CT ... chest; CT abdomen ... Treat underlying cause ... , hypotension, renal ... Oncology #HemeOnc #Diagnosis
Langerhans Cell Histiocytosis (LCH) Granulomatous Lesions comprising langerin-positive histiocytes and an inflammatory infiltrate can arise in virtually
CNS involvement: ... DIAGNOSIS • Imaging ... : X-rays, CT, or ... PET-CT / MRI: Staging ... TREATMENT OPTIONS
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
Gammopathy of Renal ... caused by nephrotoxic ... Workup: • Kidney ... clone detection • CT ... microangiopathy Treatment
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