11 results
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
Clinical history ... female, asian • Systemic ... biliary, renal, lung ... concentration PET-CT ... workup #treatment #rheumatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... effusion, Restrictive lung ... pain (20%) Renal disease ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Myositis 4% - Lung ... (aPL) 30-45% Differential ... autoantibodies #signs ... #rheumatology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... • Chronic lung ... Chest CT: • Ground-glass ... hemolytic anemia) • Systemic ... hypogammaglobulinemia #immunology #hematology
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... very remarkable w/differential ... in literature (NEJM ... day, followed by long ... them, but urgent rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... permanent alopecia Differential ... Features: Lungs ... hemorrhage • Shrinking lung ... and leukemia • Lung
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
fever syndromes Clinical ... Fever is the main clinical ... rash) • Heart, lung ... Diagnosis #Management #Hematology ... #Rheumatology
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
auricular papules Clinical ... severity of the disease ... anti-NXP2 Abs Lung ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Polycythemia - Differential Diagnosis Algorithm
Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... frequently affected systems ... Better call hematology ... , this list is long ... Algorithm #workup #hematology
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... ) • Shawl sign ... , pancreas, stomach ... , pancreas, stomach ... • Conduction system