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diagnosis differential symptoms lupus management sle vasculitis behcet classification cll hematology leukemia myopathy myositis oncology pathophysiology primary vasculitides workup
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
arthritis (RA) ... erythematosus ( ... SLE) Signs / Symptoms ... : - Lymphocyte ... #Diagnosis #Signs
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
of hip (rare), Arthritis ... Demyelinating syndromes ... pain (20%) Renal disease ... #erythematosus ... #signs #symptoms
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
dermatomyositis, Sjogren ... • Non-autoimmune ... rheumatologic diseases ... and large bowel, pancreatitis ... with Lupus: • Chronic
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... glands: • Focal lymphocytic ... Arthralgia and Arthritis ... Adenocarcinoma Treatment ... #Syndrome #Rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... rendering the immune system ... Physical Exam/Signs ... cells can indicate disease ... microglobulin Treatment
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Systemic disease ... , AS Treatment: ... Recurrent and chronic ... diagnosis #management #signs ... #symptoms #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Eosinophilia, asthma, chronic ... ischemia - Skin: erythematous ... lupus erythematosus ... purpura: strong sign ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... ischemia • Skin: Erythematous ... elevated protein, lymphocytic ... Eosinophilia, asthma, chronic ... Differential #Diagnosis #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... papules and Gottron sign ... ) • Shawl sign ... • Nonerosive arthritis ... • Conduction system
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