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causes differential coagulation abnormal management prolonged pt activation algorithm anemia arterial dic disorders disseminated elevatedmcv embolism intravascular macrocytic macrocytosis macrophage
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... antiphospholipid antibodies ... Reduced liver synthesis ... Prolonged #Causes #diagnosis ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Drugs: Direct or ... antiphospholipid antibodies ... • Reduced liver ... #differential #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... Blood Smear • Drugs ... B12 - Anti-IF Antibodies ... B12 - Anti-IF Antibodies ... Algorithm #Causes #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... cases: INR/PT, aPTT ... (liver disease, ... anti-phospholipid antibodies ... Causes #Workup #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
DIC • Severe Liver ... HIT: Heparin-PF4 antibodies ... INR < 2.3 - APTT ... #Coagulation #diagnosis ... treatment #management #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Systemic lupus erythematosus ... ) • Sepsis • Drug-induced ... thrombocytopenia • Liver ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
- Differential Diagnosis ... • Intravenous Drug ... Syndrome, Ischemic Liver ... Antiphospholipid antibodies ... pathophysiology #hematology
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