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rheumatology differential ana antinuclear causes coagulation systemic abnormal autoantibodies management patterns prolonged sle workup activation anca antibody antineutrophil arthritis bleeding
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
erythematosus ( ... disease (MCTD), Drug-induced ... #Antinuclear #Antibodies ... ANA #patterns #rheumatology ... #diagnosis #differential
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... antiphospholipid antibodies ... Reduced liver synthesis ... #Causes #diagnosis ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... PT and the aPTT ... antiphospholipid antibodies ... • Reduced liver ... #differential #hematology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... erythematosus ( ... erythematosus ( ... ANA #patterns #rheumatology ... #diagnosis #differential
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... SLE-Related Auto-Antibodies ... : Drug-induced lupus ... #Erythematosus ... #differential #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Malignancy (e.g. hematologic ... extremities Drug ... • Antihistone: Drug ... #Diagnosis #Rheumatology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... inhibitor and lupus ... Willebrand syndrome • Lupus ... #Differential #Diagnosis ... #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
) • Sepsis • Drug-induced ... thrombocytopenia • Liver ... Hypofibrinogenemia • ↑ PT ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... selected cases: INR/PT ... , aPTT(liver disease ... anti-phospholipid antibodies ... bypass), LFT (liver
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... ) • Systemic lupus ... erythematosus ... Anti-histone (in drug-induced ... #diagnosis #rheumatology
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