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diagnosis management oncology rheumatology erythematosus leukemia systemic cerebritis cll comparison differential disorders druginduced lymphocytic mds myelodysplasia myelodysplastic platelet summary syndromes
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Erythematosus (SLE ... autoantibodies that will cause ... #CNS #neurology ... #rheumatology #
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
• Immunologic Workup ... Positive in 60-80% of cases ... life-threatening • Treatment ... • Evolution: Chronic ... Management #Summary #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... peripheral blood smear ... test, ANA (e.g., SLE ... (CVID, WAS), (neurologic ... #Workup #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... • Immunologic Workup ... life-threatening • Treatment ... • Evolution: Chronic ... #table #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
peripheral blood smear ... involvement • 30%: CNS ... -> AML: Blast crises ... • Peripheral smear ... #Leukemia #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... • Peripheral smear ... microglobulin Treatment ... Leukemia #diagnosis #workup ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Peripheral Smear ... Marrow Failure • Chronic ... Workup: • Complete ... Syndromes #diagnosis #hematology
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