30 results
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Differential Diagnosis Algorithm ... / Normochromic RBCs ... on Smear • Chronic ... Spherocytes on Smear ... Differential #Diagnosis #Algorithm
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
Nephritic vs Nephrotic Syndrome ... nephrotic/nephritic syndromes ... glomerular hematuria (RBC ... or dysmorphic RBCs ... #Comparison #Algorithm
Beautiful acanthocytes/spur cells in a patient with McLeod Syndrome. X-linked disorder characterized by reduced expression of
patient with McLeod Syndrome ... expression of Kell RBC ... SpurCells #McLeod #Syndrome ... #Smear #Pathology
Plasmodium - Identification Algorithm
 • P. falciparum: RINGS AND GAMETOCYTES PREDOMINATE, Small delicate rings, <1/3 size
Identification Algorithm ... rings, <1/3 size RBC ... Multiple rings/RBC ... Identification #Algorithm ... #pathology #smear
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
2) External (RBC ... Drug-associated, PCH, Evans Syndrome ... 3) Internal (RBC ... Peripheral Blood Smear ... ↑ abnormal RBCs
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Differential Diagnosis Algorithm ... Abnormal peripheral smear ... • Extrinsic RBC ... • Intrinsic RBC ... Differential #Diagnosis #Algorithm
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Differential Diagnosis Algorithm ... Normal Blood Smear ... Neutrophils - Low RBC ... Pernicious Anemia RBCs ... Myelodysplastic Syndromes
A non-subtle example of true Sezary syndrome.  Patient presented with erythroderma without antecedent history of
of true Sezary syndrome ... mjcascio #Sezary #Syndrome ... Cells #Clinical #Pathology ... #Smear #Microscopy
Plasmodium vivax on peripheral smear
A college student presents w/ headache, fever, chills. Returned 2 days ago
on peripheral smear ... enlarged infected rbc ... patient Infected RBCs ... malaria #peripheral #smear ... blood #clinical #pathology
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
and Management Algorithm ... Initial labs: CBC ... Reticulocytes, smear ... MAHA likely: • Smear ... Diagnosis #Management #Algorithm