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diagnosis hematology management workup abdominal anemia aplastic apml bloating calcium cell cells chronic classification cll cppd deposition differential differentiation disease
hematopoiesis - leukocyte maturation tree - Amy Chung, MD, MSc @AmyChung #hematopoiesis #leukocytes #maturation #tree #pathophysiology #Hematology
Amy Chung, MD, MSc ... maturation #tree #pathophysiology ... #Hematology #Progenitor ... #Cells #WBC #pathology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... blasts and high WBC ... • Lab values: WBC ... : • Pathophysiology ... diagnosis #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Pathophysiology ... if high risk if WBC ... #oncology
Management of Abdominal Distension and Bloating - Treatment Algorithm Definitions Pathophysiology Organic/Pathologic Etiologies: • Small Intestinal Bowel Overgrowth (SIBO)
and Bloating - Treatment ... Algorithm Definitions ... Pathophysiology ... Organic/Pathologic ... Irritable Bowel Syndrome
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... Responsive to Treatment ... Amy Chung, MD, MSc ... Classification #pathophysiology ... #Hematology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... microglobulin Treatment ... • Richter’s Syndrome ... diagnosis #workup #oncology ... #hematology
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
sex • Metabolic syndrome ... Fluid Testing: • WBCs ... Dual-energy CT → MSU ... • Acute gout treatment ... #rheumatology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Disease (CPPD) Pathophysiology ... Synovial Fluid: • WBCs ... Acute Pseudogout: Treatment ... Crowned Dens Syndrome ... Deposition #Disease #Rheumatology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
• CBC + diff • ... IFE, FLC assay Pathology ... Bone marrow Treatment ... #Plasmacytoma #Oncology ... Diagnosis #Workup #Hematology
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