6 results
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
40 ml/min A - Anemia ... gamma gap (total protein ... 4 to identify hypergammaglobulinemia ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... - Hemolytic anemia ... Retiform purpura - Protein ... #Diagnosis #hematology ... #rheumatology #
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... autoimmune hemolytic anemia ... DDX - Other causes ... • Burns • Protein-losing ... #immunology #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Myeloproliferative disease ... • Nephrotic Syndrome ... intravascular coagulation ... Venous #Arterial #pathophysiology ... #hematology #differential
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
antithrombin, protein ... C and S Pathophysiology ... organ damage Clinical ... • Severe Liver Disease ... #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Causes of Monoclonal ... changes (POEMS syndrome ... gastric tumors • Hematology ... Gap #ProteinGap #differential ... #diagnosis #hematology