7 results
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
thrombin (extrinsic pathway ... FXIIa (intrinsic pathway ... clot #PT #PTT #diagnosis ... models #hematology #pathophysiology ... Edoxaban #heparin #pathway
Review of the Coagulation Cascade
Traditional Model:
 • Parallel extrinsic and intrinsic pathways.
Contemporary Model:
 • 4 key
Review of the Coagulation ... and intrinsic pathways ... models (i.e. common pathway ... #Cascade #diagnosis ... models #hematology #pathophysiology
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
disease states Pathophysiology ... activate inflammatory pathways ... culture used to diagnose ... stain and culture- Diagnose ... #rheumatology #Diagnosis
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
or alternative complement ... pathways. ... glomerular #testing #workup ... #diagnosis #glomerulonephritis
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD)

Pathophysiology:
Pyrophosphate produced by chondrocytes likely precipitates with calcium to
) Pathophysiology ... calcium to form CPP ... activate inflammatory pathways ... culture used to diagnose ... #Rheumatology #diagnosis
Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.
or alternative complement ... pathways. 6) SPEP ... glomerular #disease #workup ... #diagnosis #initial
Monoclonal Gammopathy of Renal Significance (MGRS)

MGRS
• MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
light-chain ratio Diagnostic ... Workup: • Kidney ... tubulopathy) - Complement ... pathway activation ... #Significance #Diagnosis