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diagnosis cascade hematology immunology anticoagulant anticoagulation apixaban c5c9deficiency clot dabigatran edoxaban graftversushostdisease gvhd heparin histiocytosis honc humoral huv hypocomplementemic im
Review of the Coagulation Cascade Traditional Model: • Parallel extrinsic and intrinsic pathways. Contemporary Model: • 4 key
Review of the Coagulation ... and intrinsic pathways ... (i.e. common pathway ... , resulting in coagulation ... #hematology #pathophysiology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
thrombin (extrinsic pathway ... FXIIa (intrinsic pathway ... and endothelial cells ... PTT #diagnosis #models ... Edoxaban #heparin #pathway
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... Complex Formation - Complement ... Pathway Activation ... Cytokines, Mast Cells ... perivascular inflammatory cells
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
activation • Complement ... the classical pathway ... (see Complement ... sites (e.g. lymph nodes ... Humoral #Immunity #pathophysiology
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
pathway is a non-specific ... alternative, or lectin pathway ... within bacterial cell ... leak out of the cell ... #pathophysiology
Immunosuppressive Strategies for the Prevention or Treatment of Acute GVHD. Panel A shows several classic immunosuppressive
in preclinical models ... GVHD in murine models ... different signaling pathways ... of activated T cells ... #Pathophysiology
Langerhans Cell Histiocytosis (LCH) Granulomatous Lesions comprising langerin-positive histiocytes and an inflammatory infiltrate can arise in virtually
Langerhans Cell ... of Langerhans cells ... driven by MAPK pathway ... Swollen lymph nodes ... Birbeck granules (EM
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