7 results
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
deficient patients are ... pathway is a non-specific ... alternative, or lectin pathway ... cascade -> MAC ... #pathophysiology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation cascade ... thrombin (extrinsic pathway ... FXIIa (intrinsic pathway ... models #hematology #pathophysiology ... Edoxaban #heparin #pathway
Review of the Coagulation Cascade
Traditional Model:
 • Parallel extrinsic and intrinsic pathways.
Contemporary Model:
 • 4 key
the Coagulation Cascade ... and intrinsic pathways ... upon intrinsic X-ase ... models (i.e. common pathway ... models #hematology #pathophysiology
Pathophysiology of ACE inhibitor-induced angioedema: Angioedema is a vascular reaction associated with tissue (subcutaneous, submucosal) edema
Pathophysiology ... of ACE inhibitor-induced ... substances in ACE ... through alternative pathways ... #Pathophys #EM #
Humoral Immunity - Pathogenesis and Clinical Findings
Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
Antigens (Ag) are ... molecules that are ... the classical pathway ... Memory B cells are ... Humoral #Immunity #pathophysiology
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
CPPD vs Gout ... disease states Pathophysiology ... activate inflammatory pathways ... if < 50 Years Age ... : • Advanced age
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD)

Pathophysiology:
Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Deposition Disease (CPPD ... ) Pathophysiology ... calcium to form CPP ... activate inflammatory pathways ... if < 50 years age