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diagnosis rheumatology differential management vasculitis bruising cerebritis child classification cns cryoglobulinemia cryoglobulins erythematosus essential et gammopathy glomerulonephritis hemostasis limping lupus
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
the intrinsic pathway ... the extrinsic pathway ... in the common pathway ... and extrinsic pathways ... discern these causes
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY RED FLAGS - In all cases there are specific markers which
BEARING CHILD PATHWAY ... FLAGS - In all cases ... splenomegaly, abnormal ... #Limping #NWB #Algorithm ... #Pathway #Child
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... autoantibodies that will cause ... inflammation, leading ... • Inflammatory Pathway ... cyclophosphamide • Ischemic Pathway
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... Idiopathic • Normal ... differential #diagnosis #algorithm ... #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
immune system, leading ... • They can cause ... Cryoglobulins Cause ... Through 2 Different Pathways ... • Low serum C4 complement
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
kidney disease caused ... meet criteria for hematologic ... kidney function • Abnormal ... tubulopathy) - Complement ... pathway activation
Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
Most cases are related ... JAK-STAT signaling pathway ... are usually near-normal ... • Treatment algorithms ... Thrombocythemia #ET #hematology
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