7 results
diagnosis differential bleeding bruising c5c9deficiency child coagulation essential et gammopathy glomerulonephritis hemostasis immunology limping management mgrs models monoclonal nwb pediatrics
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
fatality is rare Normal ... pathway is a non-specific ... alternative, or lectin pathway ... cascade -> MAC ... #pathophysiology
Review of the Coagulation Cascade Traditional Model: • Parallel extrinsic and intrinsic pathways. Contemporary Model: • 4 key
and intrinsic pathways ... Initiation phase caused ... models (i.e. common pathway ... diagnosis #models #hematology ... #pathophysiology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY RED FLAGS - In all cases there are specific markers which
BEARING CHILD PATHWAY ... FLAGS - In all cases ... splenomegaly, abnormal ... #Limping #NWB #Algorithm ... #Pathway #Child
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
the intrinsic pathway ... the extrinsic pathway ... in the common pathway ... and extrinsic pathways ... discern these causes
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... Idiopathic • Normal ... differential #diagnosis #algorithm ... #rheumatology
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
kidney disease caused ... meet criteria for hematologic ... kidney function • Abnormal ... tubulopathy) - Complement ... pathway activation
Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
Most cases are related ... JAK-STAT signaling pathway ... are usually near-normal ... • Treatment algorithms ... Thrombocythemia #ET #hematology
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