13 results
Complement Pathways
- Classical Pathway
- Lectin Pathway
- Alternative Pathway

#Complement #Pathway #hematology #pathophysiology
Complement Pathways ... - Classical Pathway ... - Lectin Pathway ... #Pathway #hematology ... #pathophysiology
Simplified Coagulation Cascade and Differential Diagnosis

#Coagulation #Cascade #Differential #Diagnosis #Intrinsic #Extrinsic #Pathway #Hematology
Simplified Coagulation ... Cascade and Differential ... #Cascade #Differential ... Intrinsic #Extrinsic #Pathway ... #Hematology
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... Complex Formation - Complement ... Pathway Activation ... Vasculitis #HUV #Pathophysiology ... #Rheumatology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... and extrinsic pathways ... in the common pathway ... to the common pathway ... #hematology #coagulation
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
thrombin (extrinsic pathway ... FXIIa (intrinsic pathway ... diagnosis #models #hematology ... #pathophysiology ... Edoxaban #heparin #pathway
Review of the Coagulation Cascade
Traditional Model:
 • Parallel extrinsic and intrinsic pathways.
Contemporary Model:
 • 4 key
Review of the Coagulation ... and intrinsic pathways ... models (i.e. common pathway ... diagnosis #models #hematology ... #pathophysiology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
deficiencies: Contact pathway ... to the common pathways ... intravascular coagulation ... Causes #diagnosis #differential ... #hematology #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
the intrinsic pathway ... the extrinsic pathway ... in the common pathway ... and extrinsic pathways ... #Diagnosis #Hematology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... staining): • Low Complement ... Glomerulonephritis #Vasculitis #differential ... #diagnosis #algorithm ... #rheumatology
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
CPPD vs Gout ... About CPPD When ... disease states Pathophysiology ... activate inflammatory pathways ... Gout #Comparison #rheumatology