15 results
Complement Pathways
- Classical Pathway
- Lectin Pathway
- Alternative Pathway

#Complement #Pathway #hematology #pathophysiology
Complement Pathways ... - Classical Pathway ... - Lectin Pathway ... #Pathway #hematology ... #pathophysiology
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... Complex Formation - Complement ... Pathway Activation ... Vasculitis #HUV #Pathophysiology ... #Rheumatology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
and extrinsic pathways ... in the common pathway ... to the common pathway ... amyloidosis #Abnormal ... #coagulation
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
thrombin (extrinsic pathway ... FXIIa (intrinsic pathway ... diagnosis #models #hematology ... #pathophysiology ... Edoxaban #heparin #pathway
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
the intrinsic pathway ... the extrinsic pathway ... in the common pathway ... and extrinsic pathways ... Differential #Diagnosis #Hematology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
BEARING CHILD PATHWAY ... splenomegaly, abnormal ... cell disease Rheumatology ... #Limping #NWB #Algorithm ... #Pathway #Child
Review of the Coagulation Cascade
Traditional Model:
 • Parallel extrinsic and intrinsic pathways.
Contemporary Model:
 • 4 key
Review of the Coagulation ... and intrinsic pathways ... models (i.e. common pathway ... diagnosis #models #hematology ... #pathophysiology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... deficiencies: Contact pathway ... to the common pathways ... Jcortesizaguirr #Abnormal ... #differential #hematology
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
fatality is rare Normal ... : The complement ... pathway is a non-specific ... alternative, or lectin pathway ... #pathophysiology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... Idiopathic • Normal ... Complement: IgA ... differential #diagnosis #algorithm ... #rheumatology