10 results
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Complement activation ... #Classification ... #Pathophysiology ... #Allergy #Diagnosis ... #Reactions #Table
Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the electrical system of the heart that
electrical conduction pathway ... this abnormal pathway ... resulting in a unique type ... #Pathophysiology ... #Diagnosis #Cardiology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Through 2 Different Pathways ... Labs/Diagnosis: ... • Low serum C4 complement ... Cryoglobulins #diagnosis ... #types #classification
The interferon (IFN) signature: what’s the point? How to use it in clinical practice?

Characterizing activity of
activity of IFN pathway ... understanding of pathophysiology ... To propose new classifications ... IFN #signature #diagnosis
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
function tests algorithm ... determine choice of pathway ... for users of the pathway ... disease; T2DM, type ... LFTs #Abnormal #Algorithm
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
or alternative complement ... pathways. ... cryoglobulinemias (types ... testing #workup #diagnosis
Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.
or alternative complement ... pathways. 6) SPEP ... cryoglobulinemias (types ... disease #workup #diagnosis
IGG-4 RELATED DISEASE

WHAT?
 • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
dysfunction PATHOPHYSIOLOGY ... • Pancreas: Type ... breast, skin DIAGNOSIS ... - ↑ IgE, ↓ complement ... • Classification
Monoclonal Gammopathy of Renal Significance (MGRS)

MGRS
• MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
guide subtype classification ... tubulopathy) - Complement ... pathway activation ... vasculitis Types ... #Significance #Diagnosis
6/02/2022 UPDATE: This assay is designed to detect non-variola orthopoxviruses, including monkeypox virus. It is not
2022-lab-advisory-CLARIFICATION-CDC_Publishes_Non-variola_Orthopoxvirus_PCR_Testing_Procedure ... should use this algorithm ... /pdfs/smallpox-diagnostic-algorithm-poster ... The type of specimen ... See table below