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management differential activation anemia bruising cerebritis classification cns cryoglobulinemia cryoglobulins extravascular hemolysis intravascular lupus macrophage mas nephrology neurology peds purpura
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
microangiopathy: Thrombotic thrombocytopenic ... (usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... #hematology #anemia
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
systemic lupus erythematosus ... infiltration (e.g ... Rare disorders, e.g ... - Vasculitis, e.g ... #peds #pediatrics
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
(SLE) Clinical ... Demyelinating Syndrome ... autoantibodies that will cause ... Lumbar Puncture, EEG ... CNS #neurology #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
underlying disease (eg ... • Infection (eg ... leukopenia, anemia, and thrombocytopenia ... #Diagnosis #Management ... #Hematology #Rheumatology
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
(SRC) Clinical ... microangiopathic hemolytic ... other pathology (e.g ... (short-acting, e.g ... #rheumatology #
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... : • Clinical triad ... tissue disorder (e.g ... systemic lupus erythematosus ... classification #rheumatology
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