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causes generalized monoclonal pruritus secondary aplastic chronic cll cold cutaneous disease hemolytic leukemia lymphocytic management manifestations mds mgus myelodysplasia paraproteinemias
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
of Clinical Significance ... (MGUS) - Differential ... #Clinical #Significance ... #Diagnosis #hematology ... #oncology
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
disease course • Significant ... #syndrome #differential ... #diagnosis #dermatology ... #oncology #clinical ... #skin
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Diagnosis Algorithm ... Throbocythemia • Myelodisplastic ... syndrome Psychiatric ... #generalized #dermatology ... Diagnosis #Algorithm
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Syndrome (CAS): ... Viral Infection Clinical ... younger pts) Differential ... IgM monoclonal gammopathy ... #hematology #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... of Undetermined Significance ... blood count with differential ... #Syndromes #diagnosis ... #hematology #oncology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary Skin ... Diagnosis Algorithm ... syndrome Psychiatric ... #generalized #dermatology ... Diagnosis #Algorithm
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... Headaches • Pale skin ... • Hypocellular myelodysplastic ... #oncology #hematology ... #diagnosis #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Hepatomegaly • Skin ... • Neutropenia, anemia ... #workup #oncology ... #hematology
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