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hemophagocytic oncology activation apml behcet blood calcium classification cppd deposition dermatology differentiation hodgkins lymphoma macrophage mas platelets product pseudogout pyrophosphate
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... age, however the disease ... agent are the main ... #diagnosis #management ... #treatment #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... • Autoimmune diseases ... #diagnosis #management ... #treatment #summary ... #rheumatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... → Refer to hematology ... Rebound effect from treatment ... #Diagnosis #Algorithm ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
(HLH) that develops ... SLE], AOSD) • Infection ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
) Differential Diagnosis ... Arthritis, AS Treatment ... Nonsurgical abdominal pain ... #diagnosis #management ... signs #symptoms #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... initiation • Differential ... Diagnosis: Infection ... #management #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
SAPHO Syndrome Summary ... causes such as infectious ... and lower jaw Treatment ... #Rheumatology # ... diagnosis #management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... hemolytic anemia • Pain ... number of sites of disease ... classification #hematology ... #oncology #management
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Transfusions One Pager Summary ... : Fever, flank pain ... donors (due to anti-HLA ... #Transfusions #diagnosis ... #management #hematology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Pseudogout Summary ... concomitant infection ... Crowned Dens Syndrome ... #Rheumatology # ... diagnosis #management
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