12 results
Anti-infective stewardship, including tips for using anti-infectives wisely, criteria for stepdown from IV to PO dosage
including tips for using ... anti-infectives ... #pharmacology #antibiotics ... #medications #table ... #treatment #drugs
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... usually IgG) (e.g. lupus ... ) - Drugs ( ... Beta lactam antibiotics ... #hematology #anemia
Autoimmune Hemolytic Anemia (AIHA)

WARM AHA
- Primary - Idiopathics
- Secondary
Infectious
 • Viral- HIV, EBV, HCV, HEV
 •
Autoimmune Hemolytic Anemia ... Autoimmune • Lupus ... polyangiitis Drug ... Exposure • Antibiotics ... #AIHA #Diagnosis
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
- Diagnosis Manifestations ... - Hemolytic anemia ... : Drug-induced lupus ... Other auto-immune, Infectious ... #differential #rheumatology
Penicillin Allergy Pathway for Antibiotic Prescription in Patients With Penicillin Allergy
Mild Reaction - Itching, Minor rash
Allergy Pathway for Antibiotic ... agent by microbial coverage ... interstitial nephritis, Drug ... syndrome, Hemolytic anemia ... • Avoid using
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Molecules • Ex: Antibiotic ... Autoimmune Hemolytic anemia ... Penicillin-induced drug ... • Ex: Systemic Lupus ... Arthritis, Post-infectious
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
- Cytotoxic drugs ... - β-lactam antibiotics ... Idiopathic • Infections ... #oncology #hematology ... #diagnosis #management
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Using fluorescence ... disease (MCTD), Drug-induced ... Lymphoproliferative Disorders, Infection ... ANA #patterns #rheumatology ... #diagnosis #differential
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
also be measured using ... SLE (60-70%) & drug-induced ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... fibromyalgia) • Infections ... lymphopenia, low PLT • Anemia ... extremities Drug ... #Rheumatology