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Salicylate Toxicity - Diagnosis and Management

Clinical Findings
Pathophysiology
Workup
Treatment

By Stacy Marshall, MD

#Salicylate #Toxicity #Diagnosis #Management #Toxicology #Aspirin #Treatment
Salicylate Toxicity ... - Diagnosis and ... #Toxicity #Diagnosis ... #Management #Toxicology ... #Aspirin #Treatment
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... - Diagnosis and ... #Aspirin #Toxicity ... #Toxicology #diagnosis ... #management #Treatment
Back to the "10 Need to Know" series - Drug Therapeutic Target Levels. 

For lithium, target
vary depending on treatment ... Therapeutic range ... #Ranges #Toxicology ... #Pharmacology # ... Diagnosis #Table
Carbamazepine Toxicity

Carbamazepine (CBZ) is an antiepileptic drug commonly prescribed for seizure disorders, trigeminal neuralgia, neuropathic pain,
Carbamazepine Toxicity ... receptor agonism (at therapeutic ... Carbamazepine #Toxicity ... #Toxicology #Diagnosis ... SideEffects #Adverse #Pharmacology
Therapeutic Drug Level Monitoring 
Carbamazepine - Sample immediately before next dose (trough) 
Clozapine - Sample immediately
at anytime if toxicity ... - Intermittent dosing ... #Ranges #Toxicology ... #Pharmacology # ... Diagnosis #Table
Salicylate Poisoning - Toxicology

Acute toxicity = vomiting, tachypnea, tinnitus, diaphoresis, and lethargy. This may progress to
Salicylate Poisoning ... - Toxicology ... #Toxicity #Toxicology ... #Pharmacology # ... Diagnosis #Management
Toxidromes Compared: Anticholinergic, Cholinergic, Opioid, Sympathomimetic, Sedative-Hypnotic

During your physical exam, look for evidence of some of
Sedative-Hypnotic During ... acute cholinergic toxicity ... Opioid toxicity ... #Diagnosis #Toxicology ... #Toxidromes #Comparison
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
Clozapine Toxicology ... patients who have treatment-resistant ... #Clozapine #Toxicology ... #Toxicity #Diagnosis ... #Pharmacology
Methotrexate Toxicology 

Intravenous leucovorin (folinic acid) treatment serves as a cofactor necessary for synthesis of thymidylate
Methotrexate Toxicology ... (folinic acid) treatment ... Leucovorin dosing ... #Toxicity #Management ... #Pharmacology