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differential hemophagocytic oncology treatment activation algorithm antinxp2 antinxp2dm chronic common cvid dermatomyositis extravascular gammopathies gap globulin hemeonc hemolysis hemolytic hodgkins
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
Hemophagocytic Lymphohistiocytosis ... with infection or autoimmune ... disease, treatment ... for refractory disease ... #management #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... methotrexate) • Drugs Autoimmune ... ITP • SLE • CLL ... • anti-HLA antibodies ... #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... solid cancers • Autoimmune ... diseases: SLE++ ... #diagnosis #management ... treatment #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... : HLH signs and ... Low or absent NK cell ... #diagnosis #management ... #treatment #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... ) (e.g. lupus, CLL ... Extravascular #Causes ... #hematology #anemia
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
40 ml/min A - Anemia ... diseases, CML, ... macroglobulinemia, and autoimmune ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
haemophagocytic lymphohistiocytosis ... with leukopenia, anemia ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... 5) Symptoms of anemia ... chemotherapy for low-risk disease ... Leukemia #oncology #hematology ... #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... hemolytic anemia ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Immunosuppression • Autoimmune ... ) Classification ... number of sites of disease ... #hematology #oncology ... #management
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