7 results
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Early liver disease ... Prolonged Activated Partial ... Reduced liver synthesis ... #diagnosis #differential ... #hematology #coagulation
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
- Differential ... >10 mmHg - clinically ... sarcoidosis) • Liver ... #Diagnosis #causes ... #hepatology
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
located on the dorsal ... auricular papules Clinical ... disease and ILD • Liver ... Liver biopsies show ... muscle weakness Phenotype
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
organ damage Clinical ... DIC • Severe Liver ... Treat primary cause ... INR < 2.3 - APTT ... treatment #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
of Hemostasis - Differential ... PT/NORMAL PTT: ... discern these causes ... Bruising #Hemostasis #Differential ... #Diagnosis #Hematology
Portal venous gas on hepatic ultrasound: A concerning finding in the critically ill patient that should
reflection on the differential ... variety of other causes ... venousgas #ultrasound #hepatology ... #liver #pocus # ... clinical #air
Pyogenic liver abscess in children
Common bacterial causes in children:
 • S.aureus
 • Strep spp
 • Enteric
Pyogenic liver abscess ... Common bacterial causes ... endocarditis) - Portal ... #abscess #pediatrics ... children #peds #differential