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diagnosis hepatology lfts transaminitis algorithm gastroenterology aclf acute chemistry dili drug failure function hepatitis idiosyncratic induced interpretation patterns rvalue tests
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... Injury (DILI) ... #ACLF #Acute #Chronic ... #Cirrhosis #Hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - Differential ... • NAFLD • Cirrhosis ... • Chronic Viral ... injury) • Ischemic ... #Diagnosis #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... CMV), Alcoholic cirrhosis ... 5-10x normal - Chronic ... #Injury #hepatology ... transaminitis #differential
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... presentation • Chronic ... #differential # ... Diagnosis #Management ... gastroenterology #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... hepatitis: < 1 • Cirrhosis ... : > 3 • Chronic ... #differential #
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
> 2 • NASH, Chronic ... hepatitis: < 1 • Cirrhosis ... : > 3 • Chronic ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
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