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Push Dose Pressors - Mixing Instructions - Epinephrine and Phenylephrine

Epinephrine Preparation steps:
1. Add 9 mL of
Epinephrine and Phenylephrine ... Label syringe Phenylephrine ... remove 1 mL from phenylephrine ... bag containing phenylephrine ... #Pharmacology #CriticalCare
Simplified Vasopressors and Inotropes Comparison Chart
MAP = CO x SVR
Dobutamine - Norepinephrine - Epinephrine - Phenylephrine
Epinephrine - Phenylephrine ... comparison #table #criticalcare
REBEL Review 4 & 5: Paralytic & Vasopressor Dosing 

Paralytic Agents:
 - Succinylcholine (Depolarizing Agent)
Dopamine - Phenylephrine ... resuscitation #table #criticalcare
Vasopressors and Inotropes - Comparison Table
Activity: Alpha-1, Beta-1, Dopamine, SVR, HR, CO, BP
Phenylephrine
Vasopressin
Norepinephrine
Epinephrine
Dopamine
Dobutamine
Isoproterenol
Milrinone

- Dr. Eric Strong
SVR, HR, CO, BP Phenylephrine ... #pharmacology #criticalcare
Push Dose Pressors - Mixing Instructions.

EPINEPHRINE
Has alpha and beta 1/2 effects so it is an inopressor
Do
(5-20 mcg) PHENYLEPHRINE ... draw up 1 ml of phenylephrine ... (vial contains phenylephrine ... have 100 mls of phenylephrine ... #Pharmacology #CriticalCare
Pressors and Inotropes

Norepinephrine
 • alpha1 > beta 1
 • Increase SVR > Inotropy
Vasopressin
 • V1
 •
Increase SVR Phenylephrine ... Pressors #Inotropes #criticalcare
Vasopressor Receptor Activities
alpha - beta1 - beta2 - DA - Vasopressin
Dopamine (ug/kg/min)
Epinephrine (ug/kg/min)
Norepinqhrine (ug/min)
Phenylephrine (ug/min)
Vasopressin (units/min)

#Vasopressors
Norepinqhrine (ug/min) Phenylephrine ... table #activity #criticalcare
Vasopressors and Inotropes
 • Norepinephrine - Levophed - "Levo" - Generally thought of as the first
adjunctive) • Phenylephrine ... Inotropes #management #criticalcare
Common Vasopressors and Inotropes
Norepinephrine (NE)
 - Indication: Distributive shock (1st line for septic shock), Cardiogenic shock
Peripheral ischemia Phenylephrine ... #pharmacology #criticalcare
Scleritis, Episcleritis Pearls
-Scleritis is characterized by significant pain, pain with eye movement, vision loss, and vessels
not blanch with phenylephrine ... Vessels blanch with phenylephrine