21 results
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... just beneath the skin ... that are caused ... Out Secondary Causes ... #hematology #oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... Syndrome (MD) - ... old, ~10,000 new cases ... #Syndrome #MDS ... #treatment #hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
nose chondritis, skin ... multiple myeloma, myelodysplastic ... multiple myeloma or myelodysplastic ... including peripheral blood ... Autoinflammatory #Somatic #rheumatology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Systemic and Primary Causes ... / Systemic == Blood ... Throbocythemia • Myelodisplastic ... syndrome Psychiatric ... Diagnosis #Algorithm #causes
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... Algorithm Normal Blood ... Dysplastic • Myelodysplastic ... Syndromes Macrocytosis ... #Hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
disease, Acute blood ... Hypothyroidism, Myelodysplastic ... syndrome - Dr ... differential #diagnosis #causes ... #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Headaches • Pale skin ... and petechiae Causes ... • Hypocellular myelodysplastic ... result from low blood ... #diagnosis #management
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Polyangiitis (GPA) Skin ... GPA causes disease ... • Goodpasture syndrome ... vasculitis (inflamed blood ... rash #diagnosis #rheumatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
which can plug blood ... cryoglobulins • Negative causes ... Antiphospholipid syndrome ... Warfarin-induced skin ... Cryofibrinogenemia #diagnosis #rheumatology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm

Blood Glucose:
 • Diabetes Mellitus
Liver Function Tests/Enzymes:
Pruritus - No Primary Skin ... Diagnosis Algorithm Blood ... Throbocythemia • Myelodisplastic ... syndrome Psychiatric ... Diagnosis #Algorithm #causes