103 results
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
malignancy Pathophysiology ... - GH-secreting pituitary ... (Up to 30% of pituitary ... • Pituitary ... Endocrinology #Treatment #Pathophysiology
Acromegaly 
Caused by over-secretion of growth hormone (GH) from the pituitary gland. 
The condition is rare
Acromegaly Caused ... (GH) from the pituitary ... #Acromegaly #Signs
Primary vs Secondary Adrenal Insufficiency - Pathophysiology
Primary AI = adrenal glands themselves are the problem. This
Primary vs Secondary ... Insufficiency - Pathophysiology ... Primary AI = adrenal ... Secondary AI = the pituitary ... Insufficiency #Pathophysiology
Hypothalamic releasing hormones and the pituitary trophic hormones. 

#Hypothalamic #Pituitary #Hormones #Release #Trophic #Anterior #Hypothalamus #Endocrinology
hormones and the pituitary ... #Hypothalamic #Pituitary ... Endocrinology #Pathophysiology
Multiple Endocrine Neoplasias (MEN syndromes) 

MEN I
• Hyperparathyroidism 
• Hypercalcemia 
• Possible ZE syndrome 
• Various
syndrome • Various Pituitary ... path • Acromegaly
Clinical Effects of Large and Small Pituitary Tumours
Local complications - Headache, Visual field defect, Disconnection hyperprolactinaemia,
Large and Small Pituitary ... infarction/expansion (pituitary ... Hypogonadism • Acromegaly ... and polyuria #Pituitary
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
- Giantism or acromegaly ... endocrinology #pathophysiology ... #pituitary
Causes of Primary and Secondary Amenorrhea - Differential Diagnosis Algorithm
Primary Amenorrhea - No onset of menarche
Causes of Primary ... Diagnosis Algorithm Primary ... • Central - Pituitary ... estrogen: • Pituitary ... Obstruction #Primary
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Primary Hyperthyroidism ... production by the pituitary ... Pretibial myxedema #Primary ... endocrinology #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
clinical findings • Acromegaly ... share the same pathophysiology ... plate fusion -> acromegaly ... rare causes of acromegaly ... endocrinology #pathophysiology