15 results
Immune Checkpoint Inhibitor Toxicity

Main Toxicities: Colitis,  
Pneumonitis, Skin adverse events, Endocrine dysfunction, 
Hepatitis,  
Myocarditis,
Checkpoint Inhibitor Toxicity ... Complications and Treatment ... CheckpointInhibitor #Toxicity ... Table #Diagnosis #Pharmacology ... #Oncology
TOPCAT - Spironolactone for Heart Failure with Preserved Ejection Fraction

N Engl J Med 2014; 370:1383-1392 https://www.nejm.org/doi/10.1056/NEJMoa1313731

CONCLUSIONS:
ejection fraction, treatment ... cardiovascular causes ... #HFpEF #dCHF #Cardiology ... #EBM #VisualAbstract
Testicular Cancer - Treatment Related Toxicities

Bleomycin, Cisplatin, Etoposide, lfosfamide
Tinnitus & Hearing Loss
Neurotoxicity
Pulmonary Fibrosis
Hypotension
Nephrotoxicity
Skin Hyperpigmentation
Hemorrhagic Cystitis
Myelosuppression
Peripheral Neuropathy

Ashley
Testicular Cancer - Treatment ... #chemotherapy #toxicity ... toxicology #Toxicities #pharmacology ... #oncology
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... intracellular calcium causes ... effect of digoxin toxicity ... limits so digoxin toxicity ... Pathophysiology #cardiology
Hydroxychloroquine is an antimalarial & DMARD (disease modifying antirheumatic drug). It is currently being discussed as
prophylaxis and treatment ... It also can cause ... monitor for retinal toxicity ... (increased BB toxicity ... Hydroxychloroquine #HCQ #Pharmacology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Toxic injury to BM ... and petechiae Causes ... Parvovirus B19 - EBV ... aplastic anemia Treatment ... Aplastic #Anemia #oncology
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
patients who have treatment-resistant ... Clozapine is known to cause ... #Toxicology #Toxicity ... #Diagnosis #Pharmacology
Intraoperative  Bradycardia - Guidelines for Crises in Anaesthesia
Bradycardia in theatre should not be treated as
Guidelines for Crises ... remember to tailor treatment ... Consider known drug causes ... local anaesthetic toxicity ... Management #Workup #Cardiology
Premature Ventricular Complexes (PVC's) - Summary Framework

Why PVCs?  Can be the first manifestation of cardiac
heart disease Causes ... Substances • Digoxin toxicity ... full compensatory pause ... more intensive treatment ... #differential #cardiology
Clinically Significant Cardiovascular Drug-Drug Interactions With OTC Supplements and Herbal Products
Angiotensin-Converting Enzyme Inhibitors (ACEIs)
 • Night-blooming
vera, Licorice - Causes ... risk of digoxin toxicity ... increasing risk for toxicity ... supplementals #herbal #pharmacology ... #DDI #table #cardiology