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diagnosis renal vasculitis algorithm classification clinical electronmicroscopy membranous pathology rpgn sem syndrome gbm glomerular management membranoproliferative mpgn nephrotic progressive proteinuria
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
Rapidly Progressive Glomerulonephritis ... post-infectious GN ... staining on IF • No EM ... Classification #Differential ... #Diagnosis #Nephrology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Membranoproliferative Glomerulonephritis ... formation along glomerular ... immune deposits on EM ... Membranoproliferative #Glomerulonephritis ... #MPGN #nephrology
Stage IV Glomerulonephritis on Electron Microscopy This image shows acellular scanning EM of glomerular capillary loops from
Stage IV Glomerulonephritis ... acellular scanning EM ... of glomerular capillary ... #glomerulus #MGN ... SEM #clinical #nephrology
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 Stage II Membranous Glomerulonephritis on Electron Microscopy This eyeSCANdy image shows acellular scanning EM of a glomerulus
II Membranous Glomerulonephritis ... acellular scanning EM ... of a glomerulus ... #MGN #stage2 #GBM ... SEM #clinical #nephrology
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 Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... Glomerulonephritis ... With associated pulmonary ... #Vasculitis #differential ... diagnosis #algorithm #rheumatology
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Approach to the differential ... Cytomegalovirus; GBM ... glomerulonephritis ... #Algorithm #differential ... nephrotic #syndrome #nephrology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
alveolar hemorrhage + Glomerulonephritis ... symptomatology Differential ... sclerosis • Anti-Glomerular ... anti-ANCA ab, anti-GBM ... #diagnosis #nephrology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... ) • Anti-GBM - ... Vasculitis - Skin, glomeruli ... : - Kidneys: glomerular ... #diagnosis #rheumatology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
renal failure (glomerulonephritis ... coagulopathy) • CBC w differential ... hypercellular glomeruli ... in crescentic GN ... Renal #Syndromes #differential
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Vasculitis Differential ... • Kidneys: Non-glomerular ... Anti-GBM (10 - ... #Diagnosis #Rheumatology
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