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diagnosis differential clinical causes electronmicroscopy sem glomerulonephritis glomerulus neurology algorithm cns glomerular management membranous renal acute aki classification gbm infectiousdiseases
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
(EM) Haematuria ... nephropathy • Post-infectious ... • Membranous GN ... glomerular #diseases #nephrology ... #pathology #comparison
Stage II Membranous Glomerulonephritis on Electron Microscopy This eyeSCANdy image shows acellular scanning EM of a glomerulus
Glomerulonephritis on Electron Microscopy ... appearance of GBM ... glomerulonephritis #MGN ... SEM #clinical #nephrology ... #pathology
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 Glomerulonephritis - Differential Diagnosis Framework ANCA: • C-ANCA: GPA (Wegener's) • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
Wegener's) • P-ANCA: Microscopic ... Strauss) Anti-GBM ... Mediated: • ↓C3: Infection-Related ... differential #diagnosis #nephrology
Stage III Glomerulonephritis on Electron Microscopy This image shows acellular scanning EM from a biopsy with membranous
Glomerulonephritis on Electron Microscopy ... more extensive GBM ... glomerulonephritis #MGN ... SEM #clinical #nephrology ... #pathology
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 Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
urine sediment Microscopic ... urine sediment by microscopy ... deposits - Post-infectious ... Hematuria: • Infection ... causes #urology #nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... HSP • Post-infectious ... GN - Bland urine ... #Proteinuria #Nephrology
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
toxo IgG • CNS PCR ... granulomatosis: • EBV-associated ... splenomegaly Other infections ... multiple lesions Infectious ... causes #radiology #neurology
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
cryoglobulinemia, post-infectious ... GN Anti-Glomerular ... Basement Membrane (GBM ... Linear, ribbon-like GBM ... Differential #Diagnosis #Nephrology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Vasculitis • GN ... : ANCA, Anti-GBM ... AIN: Medication, Infection ... Differential #Diagnosis #nephrology
Stage IV Glomerulonephritis on Electron Microscopy This image shows acellular scanning EM of glomerular capillary loops from
Glomerulonephritis on Electron Microscopy ... acellular scanning EM ... glomerulonephritis #glomerulus #MGN ... SEM #clinical #nephrology ... #pathology
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