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diagnosis hematology oncology causes management vasculitis algorithm classification lymphoma treatment adultonset ana antibodies antinuclear associations autoimmune cancers comparison diffuse disease
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Epidemiology: young adults ... Immunosuppression (e.g., HIV), EBV ... involvement Differential ... oncology #diagnosis #differential ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin's Lymphoma ... • History of EBV ... history • Young adults ... Immunohistochemical studies (to differentiate ... classification #hematology
Signs and Symptoms of Respiratory Distress Through the Years. #signs #symptoms #diagnosis #differential #neonatal #pediatrics #adult
symptoms #diagnosis #differential ... neonatal #pediatrics #adult ... #peds #pulmonary
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Lymphadenopathy - Differential ... Infectious • EBV ... Biopsy • Non-Hodgkin's ... Biopsy • Hodgkin's ... Algorithm #Causes #Hematology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... fraction < 20% Differential ... Coxsackie, CMV, EBV ... hepatitis • Pulmonary ... management #treatment #rheumatology
Infection-Related Cancers Viruses: • HPV - Cervical, anogenital, head and neck, skin cancer • HTLV-1 - Adult
cancer • HTLV-1 - Adult ... Kaposi's sarcoma • EBV ... - NHL, Hodgkin's ... Cancers #oncology #differential
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
to Kidney: Anti-GBM ... With associated pulmonary ... involvement: Anti-GBM ... Glomerulonephritis #Vasculitis #differential ... diagnosis #algorithm #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Infections+++: Virus (EBV ... Hemopathies+++: Hodgkin ... diseases: SLE+++, Adult-onset ... biologics (CMV +++, EBV ... treatment #summary #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
33% of healthy adults ... , Interstitial Pulmonary ... ANA #patterns #rheumatology ... #diagnosis #differential
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitides - Differential ... progressing GN • New pulmonary ... glomerulonephritis) • Anti-GBM ... ear disease Differential ... #diagnosis #rheumatology
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