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differential vasculitis classification erythematosus management sle systemic behcet criteria cryoglobulinemia cryoglobulins dermatology disease edema eularacr facial hematology monoclonal oncology paraproteinemias
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... domain: Fever • Cutaneous ... , Acute cutaneous ... Erythematosus #diagnosis ... #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
- Differential Diagnosis ... IgM deposits • Nodular ... Disease • Cogan syndrome ... #dermatology #rheumatology ... #differential #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Erythematous, macular ... Differential Diagnosis ... Non-autoimmune rheumatologic ... Erythematosus #Diagnosis ... #Rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
ulceration • Ocular ... vasculitis) • Cutaneous ... ) Differential Diagnosis ... #diagnosis #management ... signs #symptoms #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... aphthous ulcers, cutaneous ... such as systemic lupus ... strong sign of cutaneous ... #rheumatology #
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
gangrenosum • Cutaneous ... Hypergammaglobulinemic macular ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Labs/Diagnosis: ... Henoch-Schönlein purpura) • Cutaneous ... (e.g. systemic lupus ... Cryoglobulins #diagnosis ... classification #rheumatology
Facial Swelling - Differential Diagnosis Framework for Facial Edema Infectious: • Dental abscess • Ludwig's angina • Vincent's angina • Cellulitis •
- Differential Diagnosis ... Trauma: • Ocular ... head and neck • Cutaneous ... #Differential #Diagnosis ... #PhysicalExam
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... Vasculitis Differential Diagnosis ... Strong sign of cutaneous ... , ocular, articular ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Diagnosis: • Dry ... gland) biopsy • Ocular ... skin (xerosis) • Cutaneous ... #Rheumatology # ... Diagnosis #Management
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